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KMID : 0363220100480040350
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Korean Journal of Dermatology
2010 Volume.48 No. 4 p.350 ~ p.353
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Three Cases of Vitiligo Showing Response to Application of Latanoprost
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Noh Sung-Min
Oh Sang-Ho
Kim Tae-Gyun
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Abstract
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Vitiligo, which is characterized by depigmentation of skin and mucosa is a common skin disease, affecting 1-4 % of population. Although the pathogenesis is not clear, the basic defect lies in a decrease or absence of melanocytes. Vitiligo causes cosmetic disfiguration and exerts negative effects on quality of life. Phototherapy and topical agents such as corticosteroids, calcineurin inhibitors, and vitamin-D derivatives are basic treatment modalities. Recently, prostaglandin analogues have been reported to be effective on pigmentation of vitiligo lesions. We present three patients with periorbital vitiligo, who did not respond to established treatments such as tacrolimus and excimer laser, responding to application of latanoprost, a prostaglandin F2α analogue.
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KEYWORD
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Latanoprost, Prostaglandin F2α, Vitiligo
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